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Half a century of M35.4 in 10 publications.

A curated review of the scientific literature on eosinophilic fasciitis — from Shulman's 1974 description to the latest clinical reports.

10 Entries
1974 — 2024 Time span
0 Randomised trials
Filter All Reviews Cohorts Imaging Criteria Case reports
/ 01

Cornerstone publications

1975 Original description

Diffuse fasciitis with eosinophilia: a new syndrome?

Shulman LE

Trans Assoc Am Physicians · 88:70-86

Key takeaway

First description of a new syndrome — diffuse fasciitis with eosinophilia, distinguished from scleroderma by the sparing of the fingers, the absence of Raynaud's phenomenon and the dramatic response to corticosteroids.

1988 Cohort

Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases

Lakhanpal S, Ginsburg WW, Michet CJ, Doyle JA, Moore SB

Semin Arthritis Rheum · 17(4):221-231

Key takeaway

First large single-centre cohort (Mayo Clinic): 52 patients, the modern phenotype of EF — frequent flexion contractures (n = 29), associated morphea (n = 15), carpal tunnel syndrome (n = 12) and a handful of haematological associations.

2005 Imaging

Eosinophilic fasciitis: spectrum of MRI findings

Moulton SJ, Kransdorf MJ, Ginsburg WW, Abril A, Persellin S

AJR Am J Roentgenol · 184(3):975-978

Key takeaway

Reference MRI series: fascial T2 hyperintensity and post-gadolinium enhancement are characteristic findings and correlate with disease activity, supporting MRI as a non-invasive tool for both diagnosis and monitoring.

2012 Review

Eosinophilic fasciitis (Shulman disease)

Lebeaux D, Sène D

Best Pract Res Clin Rheumatol · 26(4):449-458

Key takeaway

The benchmark clinical review of the past 15 years — a synthesis of clinical presentation, the diagnostic workup and therapeutic options for what was still called Shulman disease at that time.

2014 Diagnostic criteria

Diagnosis and classification of eosinophilic fasciitis

Pinal-Fernandez I, Selva-O'Callaghan A, Grau JM

Autoimmun Rev · 13(4-5):379-382

Key takeaway

First formal set of diagnostic criteria for EF: one major criterion (skin/subcutaneous induration sparing the digits) plus minor criteria covering eosinophilia, hypergammaglobulinaemia, MRI and histology. Still the most cited framework.

2020 Cohort

Baseline characteristics and long-term outcomes of eosinophilic fasciitis in 89 patients seen at a single center over 20 years

Mango RL, Bugdayli K, Crowson CS, et al.

Int J Rheum Dis · 23(2):233-239

Key takeaway

Largest long-term cohort to date: 89 Mayo Clinic patients followed over 20 years. Most cases are self-limited once treated; combined corticosteroids and methotrexate produce the best outcomes, with disability concentrated in patients with a delayed start of therapy.

/ 02

Recent reports (2016–2024)

2016 Cohort

Epidemiology and treatment of eosinophilic fasciitis: an analysis of 63 patients from 3 tertiary care centers

Wright NA, Mazori DR, Patel M, Merola JF, Femia AN, Vleugels RA

JAMA Dermatol · 152(1):97-99

Key takeaway

Three-centre cohort, n = 63: complete remission reached 64 % under prednisone + methotrexate versus 30 % under prednisone alone, establishing combination therapy as the de-facto first line.

2017 Review

Eosinophilic fasciitis: an updated review on diagnosis and treatment

Mazori DR, Femia AN, Vleugels RA

Curr Rheumatol Rep · 19(12):74

Key takeaway

Updated practical review — diagnostic pitfalls, a treatment algorithm and a re-evaluation of biologics (rituximab, tocilizumab) for refractory disease.

2022 Review

Clinical guide to eosinophilic fasciitis: straddling dermatology and rheumatology

Onajin O, Wieland CN, Peters MS, Lehman JS, Gibson LE

Expert Rev Clin Immunol · 18(7):707-718

Key takeaway

Joint dermatology–rheumatology guide: the practical handbook for the clinician seeing the patient for the first time, with photo-illustrated criteria and a graded decision algorithm.

2024 Case series

Eosinophilic fasciitis following COVID-19: a case series of 3 patients

Li Y, Kong HE, Cheeley J

JAAD Case Rep · 44:6-10

Key takeaway

Three patients developing EF after a SARS-CoV-2 infection — the first published series supporting a viral trigger for the disease in part of the population.